1-benzyl-6-carbomethoxy methyl tetrahydroisoquinoline derivative, preparation method and application in resisting aggregation of thrombocyte

The invention belongs to the field of medicine synthesis, and provides a 1-benzyl-6-carbomethoxy methyl tetrahydroisoquinoline derivative, a preparation method and an application in resisting aggregation of thrombocyte, and particularly relates to a novel 1-substituted-benzyl-N-alkyl (acyl)-6-carbomethoxy methyl-7-methoxyl-1,2,3,4-tetrahydroisoquinoline derivative as shown in the formula (see the specification), a preparation method and an application for resisting the aggregation activity of the thrombocyte. According to the derivative, the in-vitro thrombocyte aggregation-resisting activity is tested by virtue of a Born turbidimetry, a test result shows that the derivative has the thrombocyte aggregation resisting activity, and the activity is obviously higher than positive reference clopidogrel sulfate. The nitrogen decoration of the 1-benzyl-6-carbomethoxy methyl tetrahydroisoquinoline derivative is favorable for improving the thrombocyte aggregation resisting activity. The 1-benzyl-6-carbomethoxy methyl tetrahydroisoquinoline derivative can be used for further preparing an antithrombus drug and has a good practical value and application prospect.