固载钯催化剂在4-苯乙炔基-3-硝基苯甲酸甲酯合成中的应用

本发明提供种固载钯催化剂在4-苯乙炔基-3-硝基苯甲酸甲酯合成中的应用。所述固载钯催化剂指的是钯(II)印迹聚合物，所述钯(II)印迹聚合物指的是大分子侧链上含有叔胺基、季铵阳离子和水杨醛肟合钯(II)印迹聚合物，应用于催化4-氯-3-硝基苯甲酸甲酯、碘化钾或碘化钠和苯乙炔之间的串联反应，合成4-苯乙炔基3-硝基苯甲酸甲酯，该固载钯催化剂具有合成技术简便，催化活性稳定，易于再生，串联反应产物收率高，原料与产物间分离简便，原料单耗低的特点。 The invention provides an application of an immobilized palladium catalyst in synthesis of methyl 4-phenylethynyl-3-nitrobenzoate. The immobilized palladium catalyst refers to a palladium (II) imprinted polymer of which a macromolecular side chain contains a tertiary amine group, a quaternary ammonium cation and salicylaldoximate palladium (II). The catalyst is applied in a cascade reaction among methyl 4-chloro-3-nitrobenzoate, potassium iodide or sodium iodide, and phenylacetylene to synthesize the methyl 4-phenylethynyl-3-nitrobenzoate. The immobilized palladium catalyst is simple in synthesis technology, is stable in catalytic activity, is easy to regenerate, is high in yield of a cascade reaction product, is simple in separation between raw materials and products, and is low in unit con