Mesenchymal stem cell excreted factor essence, and preparation method and application thereof

The invention provides mesenchymal stem cell excreted factor essence. The mesenchymal stem cell excreted factor essence comprises vascular endothelial growth factors with concentration range of 11.4-0.4ng/ml, epidermal growth factors with concentration range of 6.2-1.0ng/ml, fibroblast growth factors with concentration range of 8.5-2.4ng/ml, heaptocyte growth factors with concentration range of 40.8-0.6ng/ml, interleukin 6 with concentration range of 17.1-1.5ng/ml and interleukin 8 with concentration range of 32.3-0.4ng/ml. The essence prepared by the method has effects of nourishing skin, clearing away wrinkles and resisting aging, and has the advantages of free side effects and high stability; skins of users cannot be allergic easily; and the mesenchymal stem cell excreted factor essence can be used for whitening skin and resisting aging.