Pyrazolyl-ureas as kinase inhibitors

There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and membe...

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Hauptverfasser:	CARIOU CLAIRE ANNE MARIE, FYFE MATTHEW COLIN THOR, HAMZA DANIEL, WATSON HAYLEY TEGAN ANGELA, FORDYCE EUAN ALEXANDER FRASER, THOM STEPHEN MALCOLM, MURRAY PETER JOHN, CHARRON CATHERINE ELISABETH, ITO KAZUHIRO, ONIONS STUART THOMAS, WILLIAMS JONATHAN GARETH, KING-UNDERWOOD JOHN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.