Additive for increasing fermentative yield of epothilone and application thereof
The invention discloses an additive for increasing the fermentative yield of epothilone, which is indoleacetic acid, indole methyl formate or indole, and the added final concentration of the additive in epothilone liquid fermentation medium is 20 plus/minus 3Mu mol/L. An experiment proves that the a...
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Zusammenfassung: | The invention discloses an additive for increasing the fermentative yield of epothilone, which is indoleacetic acid, indole methyl formate or indole, and the added final concentration of the additive in epothilone liquid fermentation medium is 20 plus/minus 3Mu mol/L. An experiment proves that the additive disclosed by the invention can promote thalli to absorb and utilize nutrient substances and enhance the secondary metabolism of sprangium cellulosums, so that the total amount of epothilone is increased by 2 to 19 percent on average in comparison with the total amount of epothilone not added with the additive. The additive provided by the invention reduces fermentation cost, increases the yield of epothilone, and provides another approach for epothilone production. |
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