Quinoline ring-oxazolone ring compound and its preparation method and use

The invention discloses a quinoline ring-oxazolone ring compound and its preparation method. The preparation method comprises that mefloquine shown in the formula (A) is dissolved in a first reaction solvent, triethylamine is added into the solution, the mixed solution undergoes a reaction to produc...

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Hauptverfasser: GUAN FENGJIE, HU WENHAO, LIU SHUNYING, LYU FENGPING, ZHANG XIONGWEN, LEI YUBING
Format: Patent
Sprache:eng
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Zusammenfassung:The invention discloses a quinoline ring-oxazolone ring compound and its preparation method. The preparation method comprises that mefloquine shown in the formula (A) is dissolved in a first reaction solvent, triethylamine is added into the solution, the mixed solution undergoes a reaction to produce a compound shown in the formula (B), the compound shown in the formula (B) is dissolved in a second reaction solvent, Dess-Martin periodinane is added into the solution, the mixed solution undergoes a reaction to produce a compound shown in the formula (C), the compound shown in the formula (C) is dissolved in a third reaction solvent, a sodium hydroxide solution is added into the solution, and the mixed solution undergoes a reaction to produce the quinoline ring-oxazolone ring compound shown in the formula (D). The preparation method of the quinoline ring-oxazolone ring compound shown in the formula (D) has the characteristics of cheap and easily available raw materials, short preparation route, simple operation, mild reaction conditions, high atom economy, high yield and no environmental pollution. The quinoline ring-oxazolone ring compound shown in the formula (D) is a novel fluorescence chromophore, has a high quantum yield, can give out light in a solid form and has wide Stock displacement. The invention also provides use of the quinoline ring-oxazolone ring compound shown in the formula (D) in cancer cell fluorescence imaging.