New application of ethyl 4-hydroxybenzoate to pharmacy

The invention relates to new application of ethyl 4-hydroxybenzoate to pharmacy, and belongs to the field of medicine. Ethyl 4-hydroxybenzoate has the control effect on diabetic nephropathy, can inhibit glomerular mesangial cell multiplication and endothelial cell apoptosis caused by AGEs (Advanced...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN DANYANG, QU XIAJING, GAO XUEHUI, CHENG HUIKUI, ZHU KUI, GU FEI, DUAN TINGTING, WANG RUSHANG, GAO JUNFEI, HU QIN, YANG DAN, YANG LINLIN, HE BAO, ZHENG ZHAOGUANG, SHI XINGHUA
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to new application of ethyl 4-hydroxybenzoate to pharmacy, and belongs to the field of medicine. Ethyl 4-hydroxybenzoate has the control effect on diabetic nephropathy, can inhibit glomerular mesangial cell multiplication and endothelial cell apoptosis caused by AGEs (Advanced Glycation End Products), can reduce endothelial cell oxidative stress level caused by AGEs, and can improve rat urine protein, urine creatinine, serum creatinine and creatinine clearance rates and blood glucose and blood pressure abnormality, caused by STZ-CFA, of a diabetic nephropathy model. Medicine compositions can be prepared from ethyl 4-hydroxybenzoate and drug carriers, so that various oral dosage forms such as granule, tablet, capsule and pill can be prepared; the use is convenient, safe and reliable.