Ribonucleic acids with 4'-thio-modified nucleotides and related methods

Ribonucleic acids with 4'-thio-modified nucleotides and related methods

Disclosed are messenger RNA molecules and related compositions incorporating a 4'-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mRNAs to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders. In certa...

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Hauptverfasser: NGUYEN KHANG V, KAJARIA SAURABH, BORAK EUGENE A
Format: Patent
Sprache:eng
Schlagworte:
EARTH DRILLING
EARTH DRILLING, e.g. DEEP DRILLING
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OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR ASLURRY OF MINERALS FROM WELLS
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Zusammenfassung:Disclosed are messenger RNA molecules and related compositions incorporating a 4'-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mRNAs to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders. In certain embodiments, the 4'-thio modified mRNA provides for enhanced stability and/or reduced immunogenicity in in vivo therapies.