Synthesis methods of 4-androsten-3-one-17-beta-carboxylic acid and methyl 4-androsten-3-one-17-beta-carboxylate
The invention relates to synthesis methods of 4-androsten-3-one-17-beta-carboxylic acid and methyl 4-androsten-3-one-17-beta-carboxylate. Cheap testosterone as a raw material undergoes a chlorination reaction, the reaction product is subjected to etherification protection and the branched chain at t...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | The invention relates to synthesis methods of 4-androsten-3-one-17-beta-carboxylic acid and methyl 4-androsten-3-one-17-beta-carboxylate. Cheap testosterone as a raw material undergoes a chlorination reaction, the reaction product is subjected to etherification protection and the branched chain at the 17 site of androstane is modified by a Grignard addition method so that 4-androsten-3-one-17-beta-carboxylic acid and methyl 4-androsten-3-one-17-beta-carboxylate are synthesized. The synthesis methods have the advantages of novel and short processes, high yield, economical efficiency, environmental friendliness and industrialization feasibility. |
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