Bruton's tyrosine kinase inhibitors
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in comb...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ZAPF CHRISTOPH WOLFGANG SCHMIDT MICHELLE ANN SPRINGER JOHN ROBERT HUGHES ROBERT OWEN WAN ZHAO-KUI SELNESS SHAUN RAJ GARLAND DANNY JAMES DEVADAS BALEKUDRU GRAPPERHAUS MARGARET LANAHAN SAIAH EDDINE WALKER DANIEL PATRICK HOCKERMAN SUSAN LANDIS HAN SEUNGIL SCHNUTE MARK EDWARD XING LI |
| description | Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I) |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN105008344A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN105008344A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN105008344A3</originalsourceid><addsrcrecordid>eNrjZFB2Kiotyc9TL1YoqSzKL87MS1XIzsxLLE5VyMzLyEzKLMkvKuZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGpgYGFsYmJo7GxKgBAPr8JqM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Bruton's tyrosine kinase inhibitors</title><source>esp@cenet</source><creator>ZAPF CHRISTOPH WOLFGANG ; SCHMIDT MICHELLE ANN ; SPRINGER JOHN ROBERT ; HUGHES ROBERT OWEN ; WAN ZHAO-KUI ; SELNESS SHAUN RAJ ; GARLAND DANNY JAMES ; DEVADAS BALEKUDRU ; GRAPPERHAUS MARGARET LANAHAN ; SAIAH EDDINE ; WALKER DANIEL PATRICK ; HOCKERMAN SUSAN LANDIS ; HAN SEUNGIL ; SCHNUTE MARK EDWARD ; XING LI</creator><creatorcontrib>ZAPF CHRISTOPH WOLFGANG ; SCHMIDT MICHELLE ANN ; SPRINGER JOHN ROBERT ; HUGHES ROBERT OWEN ; WAN ZHAO-KUI ; SELNESS SHAUN RAJ ; GARLAND DANNY JAMES ; DEVADAS BALEKUDRU ; GRAPPERHAUS MARGARET LANAHAN ; SAIAH EDDINE ; WALKER DANIEL PATRICK ; HOCKERMAN SUSAN LANDIS ; HAN SEUNGIL ; SCHNUTE MARK EDWARD ; XING LI</creatorcontrib><description>Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151028&DB=EPODOC&CC=CN&NR=105008344A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151028&DB=EPODOC&CC=CN&NR=105008344A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZAPF CHRISTOPH WOLFGANG</creatorcontrib><creatorcontrib>SCHMIDT MICHELLE ANN</creatorcontrib><creatorcontrib>SPRINGER JOHN ROBERT</creatorcontrib><creatorcontrib>HUGHES ROBERT OWEN</creatorcontrib><creatorcontrib>WAN ZHAO-KUI</creatorcontrib><creatorcontrib>SELNESS SHAUN RAJ</creatorcontrib><creatorcontrib>GARLAND DANNY JAMES</creatorcontrib><creatorcontrib>DEVADAS BALEKUDRU</creatorcontrib><creatorcontrib>GRAPPERHAUS MARGARET LANAHAN</creatorcontrib><creatorcontrib>SAIAH EDDINE</creatorcontrib><creatorcontrib>WALKER DANIEL PATRICK</creatorcontrib><creatorcontrib>HOCKERMAN SUSAN LANDIS</creatorcontrib><creatorcontrib>HAN SEUNGIL</creatorcontrib><creatorcontrib>SCHNUTE MARK EDWARD</creatorcontrib><creatorcontrib>XING LI</creatorcontrib><title>Bruton's tyrosine kinase inhibitors</title><description>Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB2Kiotyc9TL1YoqSzKL87MS1XIzsxLLE5VyMzLyEzKLMkvKuZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGpgYGFsYmJo7GxKgBAPr8JqM</recordid><startdate>20151028</startdate><enddate>20151028</enddate><creator>ZAPF CHRISTOPH WOLFGANG</creator><creator>SCHMIDT MICHELLE ANN</creator><creator>SPRINGER JOHN ROBERT</creator><creator>HUGHES ROBERT OWEN</creator><creator>WAN ZHAO-KUI</creator><creator>SELNESS SHAUN RAJ</creator><creator>GARLAND DANNY JAMES</creator><creator>DEVADAS BALEKUDRU</creator><creator>GRAPPERHAUS MARGARET LANAHAN</creator><creator>SAIAH EDDINE</creator><creator>WALKER DANIEL PATRICK</creator><creator>HOCKERMAN SUSAN LANDIS</creator><creator>HAN SEUNGIL</creator><creator>SCHNUTE MARK EDWARD</creator><creator>XING LI</creator><scope>EVB</scope></search><sort><creationdate>20151028</creationdate><title>Bruton's tyrosine kinase inhibitors</title><author>ZAPF CHRISTOPH WOLFGANG ; SCHMIDT MICHELLE ANN ; SPRINGER JOHN ROBERT ; HUGHES ROBERT OWEN ; WAN ZHAO-KUI ; SELNESS SHAUN RAJ ; GARLAND DANNY JAMES ; DEVADAS BALEKUDRU ; GRAPPERHAUS MARGARET LANAHAN ; SAIAH EDDINE ; WALKER DANIEL PATRICK ; HOCKERMAN SUSAN LANDIS ; HAN SEUNGIL ; SCHNUTE MARK EDWARD ; XING LI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105008344A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZAPF CHRISTOPH WOLFGANG</creatorcontrib><creatorcontrib>SCHMIDT MICHELLE ANN</creatorcontrib><creatorcontrib>SPRINGER JOHN ROBERT</creatorcontrib><creatorcontrib>HUGHES ROBERT OWEN</creatorcontrib><creatorcontrib>WAN ZHAO-KUI</creatorcontrib><creatorcontrib>SELNESS SHAUN RAJ</creatorcontrib><creatorcontrib>GARLAND DANNY JAMES</creatorcontrib><creatorcontrib>DEVADAS BALEKUDRU</creatorcontrib><creatorcontrib>GRAPPERHAUS MARGARET LANAHAN</creatorcontrib><creatorcontrib>SAIAH EDDINE</creatorcontrib><creatorcontrib>WALKER DANIEL PATRICK</creatorcontrib><creatorcontrib>HOCKERMAN SUSAN LANDIS</creatorcontrib><creatorcontrib>HAN SEUNGIL</creatorcontrib><creatorcontrib>SCHNUTE MARK EDWARD</creatorcontrib><creatorcontrib>XING LI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZAPF CHRISTOPH WOLFGANG</au><au>SCHMIDT MICHELLE ANN</au><au>SPRINGER JOHN ROBERT</au><au>HUGHES ROBERT OWEN</au><au>WAN ZHAO-KUI</au><au>SELNESS SHAUN RAJ</au><au>GARLAND DANNY JAMES</au><au>DEVADAS BALEKUDRU</au><au>GRAPPERHAUS MARGARET LANAHAN</au><au>SAIAH EDDINE</au><au>WALKER DANIEL PATRICK</au><au>HOCKERMAN SUSAN LANDIS</au><au>HAN SEUNGIL</au><au>SCHNUTE MARK EDWARD</au><au>XING LI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Bruton's tyrosine kinase inhibitors</title><date>2015-10-28</date><risdate>2015</risdate><abstract>Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_CN105008344A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Bruton's tyrosine kinase inhibitors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T05%3A59%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ZAPF%20CHRISTOPH%20WOLFGANG&rft.date=2015-10-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN105008344A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |