Bruton's tyrosine kinase inhibitors

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in comb...

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Bibliographische Detailangaben
Hauptverfasser:	ZAPF CHRISTOPH WOLFGANG, SCHMIDT MICHELLE ANN, SPRINGER JOHN ROBERT, HUGHES ROBERT OWEN, WAN ZHAO-KUI, SELNESS SHAUN RAJ, GARLAND DANNY JAMES, DEVADAS BALEKUDRU, GRAPPERHAUS MARGARET LANAHAN, SAIAH EDDINE, WALKER DANIEL PATRICK, HOCKERMAN SUSAN LANDIS, HAN SEUNGIL, SCHNUTE MARK EDWARD, XING LI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)