Preparation and application of magnetic graphene oxide compound

The invention relates to preparation and application of a reusable drug carrier with magnetic targeting drug delivery, namely a magnetic graphene oxide compound. The preparation of the magnetic graphene oxide compound comprises the following steps: (1) taking a graphite powder, adding a concentrated...

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Bibliographische Detailangaben
Hauptverfasser: LI LIANGCHAO, ZHANG JINMIN, QUAN WEILEI, FENG JIANTAO, SHEN JUNHAI
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to preparation and application of a reusable drug carrier with magnetic targeting drug delivery, namely a magnetic graphene oxide compound. The preparation of the magnetic graphene oxide compound comprises the following steps: (1) taking a graphite powder, adding a concentrated H2SO4 solution with NaNO3 dissolved therein, stirring, adding KMnO4, reacting, adding distilled water for dilution, keeping warm, cooling to room temperature, adding H2O2 to react, conducting suction filtration, washing respectively with diluted hydrochloric acid and distilled water, carrying out vacuum drying to obtain graphite oxide; dispersing graphite oxide in deionized water, and carrying out ultrasonic exfoliation at room temperature to obtain a GO suspension; (2) respectively weighing ferrous salt and ferric salt and dissolving in deionized water to obtain a solution A; and (3) taking a GO suspension, adding distilled water for dilution, adjusting to acid, dropwise adding the solution A obtained in the step (2) so as to obtain a mixed solution B, carrying out constant temperature curing on the mixed solution B, adjusting to alkaline, ageing for several hours, carrying out magnetic separation to obtain a solid crude product, washing the solid crude product to neutral, and carrying out vacuum drying to obtain the product.