Ceftiofur hydrochloride liposome lyophilized agent and preparation method thereof

The invention discloses a ceftiofur hydrochloride liposome lyophilized agent and a preparation method thereof. The ceftiofur hydrochloride liposome lyophilized agent comprises, by weight, 3-10 parts of ceftiofur hydrochloride, 15-100 parts of lecithin, 15-100 parts of cholesterols, and 4.5-13.5 parts of polyvinyl alcohol 2000. The preparation method comprises the following steps: dissolving ceftiofur hydrochloride, lecithin and cholesterols, mixing, carrying out vacuum drying, and adding a phosphate buffer solution of polyethylene glycol 2000 to prepare a liposome suspension; and adding a lyophilizing protection agent to the suspension, uniformly mixing, packaging the obtained solution to a penicillin bottle, putting the penicillin bottle provided with the solution in a lyophilizer, and drying to obtain the ceftiofur hydrochloride liposome-carried lyophilized agent. The liposome entrapment rate is good, and a result of long-term stabilization investigation of the liposome lyophilized agent shows that the stability of the liposome lyophilized agent is good; and the lyophilized agent re-dissolved in a liquid medium has the characteristics of good dispersion and stable properties. Clinic curative effect tests prove that compared with suspensions, the liposome lyophilized agent has the advantages of prolonged circulation time in an administrated body, and definite therapeutic effect on porcine respiratory diseases induced by bacterial infection.