Amoxicillin slow release pellet and preparation method thereof

The invention discloses an amoxicillin slow release pellet. The amoxicillin slow release pellet is composed of a drug-containing pellet core, an isolation coating layer and a slow release coating layer from inside to outside; and the drug-containing pellet core is composed of 50.0-95.0wt% of amoxicillin, 0.5-5.0wt% of an adhesive, 0.5-5.0wt% of a flow aid and 4.0-40.0wt% of a filler. Slow release pellets of the above amoxicillin slow release pellet preparation are composed of pellets with different drug release rates, the drug release rates can reach zero order, and no time lag phenomenon exists. A multi-dosage dosage form is difficultly influenced by the rhythm of the alimentary canal, and interference of the gastric emptying rate can be neglected. The drug content of the amoxicillin slow release pellets is 1% ~ above 95%, and the maximum dosage in a single capsule can reach 600mg and is far greater than that of other drug dosage forms.