Method for synthesizing beta-branched chain alpha-amino ester
The invention discloses a method for synthesizing a beta-branched chain alpha-amino ester. With beta-branched chain alpha-keto ester and benzylamine as raw materials, and cinchona alkaloid-derived chiral base as a catalyst, asymmetric trans-ammoniation reaction is carried out by catalyzing beta-bran...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SHI YIAN SU CUNXIANG PAN HONGJIE XIE YING LIU MAO TIAN HUA |
| description | The invention discloses a method for synthesizing a beta-branched chain alpha-amino ester. With beta-branched chain alpha-keto ester and benzylamine as raw materials, and cinchona alkaloid-derived chiral base as a catalyst, asymmetric trans-ammoniation reaction is carried out by catalyzing beta-branched chain alpha-keto esters with different structures by a one-pot method; a photoactive beta-branched chain alpha-amino ester is prepared by a plurality of after-treatment steps such as hydrolysis, extraction and column chromatography; a photoactive beta-branched chain alpha-amino acid can be obtained by further hydrolysis of the amino ester; the productive rate can be up to 96%; and the enantiomer excess value can be up to 95%. The formula is shown in the specification. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN104974001A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN104974001A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN104974001A3</originalsourceid><addsrcrecordid>eNrjZLD1TS3JyE9RSMsvUiiuzCvJSC3OrMrMS1dISi1J1E0qSsxLzkhNUUjOSMzMU0jMKchI1E3MzczLV0gtLkkt4mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hgYmluYmBgaGjsbEqAEAIa4wHA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Method for synthesizing beta-branched chain alpha-amino ester</title><source>esp@cenet</source><creator>SHI YIAN ; SU CUNXIANG ; PAN HONGJIE ; XIE YING ; LIU MAO ; TIAN HUA</creator><creatorcontrib>SHI YIAN ; SU CUNXIANG ; PAN HONGJIE ; XIE YING ; LIU MAO ; TIAN HUA</creatorcontrib><description>The invention discloses a method for synthesizing a beta-branched chain alpha-amino ester. With beta-branched chain alpha-keto ester and benzylamine as raw materials, and cinchona alkaloid-derived chiral base as a catalyst, asymmetric trans-ammoniation reaction is carried out by catalyzing beta-branched chain alpha-keto esters with different structures by a one-pot method; a photoactive beta-branched chain alpha-amino ester is prepared by a plurality of after-treatment steps such as hydrolysis, extraction and column chromatography; a photoactive beta-branched chain alpha-amino acid can be obtained by further hydrolysis of the amino ester; the productive rate can be up to 96%; and the enantiomer excess value can be up to 95%. The formula is shown in the specification.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151014&DB=EPODOC&CC=CN&NR=104974001A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151014&DB=EPODOC&CC=CN&NR=104974001A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHI YIAN</creatorcontrib><creatorcontrib>SU CUNXIANG</creatorcontrib><creatorcontrib>PAN HONGJIE</creatorcontrib><creatorcontrib>XIE YING</creatorcontrib><creatorcontrib>LIU MAO</creatorcontrib><creatorcontrib>TIAN HUA</creatorcontrib><title>Method for synthesizing beta-branched chain alpha-amino ester</title><description>The invention discloses a method for synthesizing a beta-branched chain alpha-amino ester. With beta-branched chain alpha-keto ester and benzylamine as raw materials, and cinchona alkaloid-derived chiral base as a catalyst, asymmetric trans-ammoniation reaction is carried out by catalyzing beta-branched chain alpha-keto esters with different structures by a one-pot method; a photoactive beta-branched chain alpha-amino ester is prepared by a plurality of after-treatment steps such as hydrolysis, extraction and column chromatography; a photoactive beta-branched chain alpha-amino acid can be obtained by further hydrolysis of the amino ester; the productive rate can be up to 96%; and the enantiomer excess value can be up to 95%. The formula is shown in the specification.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD1TS3JyE9RSMsvUiiuzCvJSC3OrMrMS1dISi1J1E0qSsxLzkhNUUjOSMzMU0jMKchI1E3MzczLV0gtLkkt4mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hgYmluYmBgaGjsbEqAEAIa4wHA</recordid><startdate>20151014</startdate><enddate>20151014</enddate><creator>SHI YIAN</creator><creator>SU CUNXIANG</creator><creator>PAN HONGJIE</creator><creator>XIE YING</creator><creator>LIU MAO</creator><creator>TIAN HUA</creator><scope>EVB</scope></search><sort><creationdate>20151014</creationdate><title>Method for synthesizing beta-branched chain alpha-amino ester</title><author>SHI YIAN ; SU CUNXIANG ; PAN HONGJIE ; XIE YING ; LIU MAO ; TIAN HUA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN104974001A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>SHI YIAN</creatorcontrib><creatorcontrib>SU CUNXIANG</creatorcontrib><creatorcontrib>PAN HONGJIE</creatorcontrib><creatorcontrib>XIE YING</creatorcontrib><creatorcontrib>LIU MAO</creatorcontrib><creatorcontrib>TIAN HUA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHI YIAN</au><au>SU CUNXIANG</au><au>PAN HONGJIE</au><au>XIE YING</au><au>LIU MAO</au><au>TIAN HUA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for synthesizing beta-branched chain alpha-amino ester</title><date>2015-10-14</date><risdate>2015</risdate><abstract>The invention discloses a method for synthesizing a beta-branched chain alpha-amino ester. With beta-branched chain alpha-keto ester and benzylamine as raw materials, and cinchona alkaloid-derived chiral base as a catalyst, asymmetric trans-ammoniation reaction is carried out by catalyzing beta-branched chain alpha-keto esters with different structures by a one-pot method; a photoactive beta-branched chain alpha-amino ester is prepared by a plurality of after-treatment steps such as hydrolysis, extraction and column chromatography; a photoactive beta-branched chain alpha-amino acid can be obtained by further hydrolysis of the amino ester; the productive rate can be up to 96%; and the enantiomer excess value can be up to 95%. The formula is shown in the specification.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_CN104974001A |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
| title | Method for synthesizing beta-branched chain alpha-amino ester |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T03%3A06%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SHI%20YIAN&rft.date=2015-10-14&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN104974001A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |