Method for synthesizing beta-branched chain alpha-amino ester

The invention discloses a method for synthesizing a beta-branched chain alpha-amino ester. With beta-branched chain alpha-keto ester and benzylamine as raw materials, and cinchona alkaloid-derived chiral base as a catalyst, asymmetric trans-ammoniation reaction is carried out by catalyzing beta-bran...

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Bibliographische Detailangaben
Hauptverfasser: SHI YIAN, SU CUNXIANG, PAN HONGJIE, XIE YING, LIU MAO, TIAN HUA
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention discloses a method for synthesizing a beta-branched chain alpha-amino ester. With beta-branched chain alpha-keto ester and benzylamine as raw materials, and cinchona alkaloid-derived chiral base as a catalyst, asymmetric trans-ammoniation reaction is carried out by catalyzing beta-branched chain alpha-keto esters with different structures by a one-pot method; a photoactive beta-branched chain alpha-amino ester is prepared by a plurality of after-treatment steps such as hydrolysis, extraction and column chromatography; a photoactive beta-branched chain alpha-amino acid can be obtained by further hydrolysis of the amino ester; the productive rate can be up to 96%; and the enantiomer excess value can be up to 95%. The formula is shown in the specification.