A 1,4,5-TRISUBSTITUTED1,2,3-TRIAZOLE MIMETIC OF RGD AND/OR OGP10-14, PROCESS TO OBTAIN IT AND USES THEREOF

The present invention relates to nonpeptide compounds of formula (I), containing a central 1,4,5- trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent ''click'' bonds on the surface of materials functionalized with reactive groups including: az...

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Bibliographische Detailangaben
Hauptverfasser:	OYARBIDE VICU A JOSEBA, AIZPURUA IPARRAGUIRRE JES S MARIA, BRACERAS IZAGUIRRE I IGO, FERNANDEZ OYON XAVIER, AZPIROZ DORRONSORO FRANCISCO JAVIER, SAGARTZAZU AIZPURUA MAIALEN
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC CHEMISTRY ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROSTHESES TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	The present invention relates to nonpeptide compounds of formula (I), containing a central 1,4,5- trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent ''click'' bonds on the surface of materials functionalized with reactive groups including: azide, terminal alkyne, cyclooctalkyne, thiol, maleimide or thiolacid groups. These compounds are nonpeptide mimetics of RGD (Arg-Gly- Asp) and/or OGP10-14 (Tyr-Gly-Phe-Gly-Gly), osteogenic peptides. Also, the present invention relates to a process for the preparation of the compounds containing a 1,4,5-trisubstituted 1,2,3-triazole core. These compounds are particularly useful for medical devices, in particular implants and tissue engineering and cell culture matrices.