Preparation method of hydroxyapatite-enhanced keratin composite aggregate

The invention provides a preparation method of a hydroxyapatite-enhanced keratin composite aggregate. The method specifically comprises the following steps: adding hydroxyapatite powder to a keratin solution which is extracted from a natural keratin fiber by a reduction method, and mixing the hydrox...

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Hauptverfasser:	ZHAI PEIYU, YU XIA, FAN JIE, LIU YONG, LEI TONGDA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
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creator	ZHAI PEIYU YU XIA FAN JIE LIU YONG LEI TONGDA
description	The invention provides a preparation method of a hydroxyapatite-enhanced keratin composite aggregate. The method specifically comprises the following steps: adding hydroxyapatite powder to a keratin solution which is extracted from a natural keratin fiber by a reduction method, and mixing the hydroxyapatite powder with the keratin solution evenly through ultrasonic dispersion; injecting a mixed solution into a mold, rapidly freezing, and then obtaining a hydroxyapatite/keratin composite porous material through a freeze-drying method; and soaking the composite porous material into a PBS (poly butylenes succinate) (pH=7.4) solution, carrying out enhancing treatment, and then carrying out freeze-drying again to obtain the hydroxyapatite-enhanced keratin composite aggregate with good mechanical property. Compared with an un-enhanced hydroxyapatite/keratin composite porous material, the enhanced composite scaffold is not fragile; the compressive strength range is 200-800KPa; the requirements of the mechanical property of a non-bearing skeleton in short-term repairing and using processes can be met; and application of the hydroxyapatite/keratin composite biological scaffold material as a bone substitution material is promoted.
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The method specifically comprises the following steps: adding hydroxyapatite powder to a keratin solution which is extracted from a natural keratin fiber by a reduction method, and mixing the hydroxyapatite powder with the keratin solution evenly through ultrasonic dispersion; injecting a mixed solution into a mold, rapidly freezing, and then obtaining a hydroxyapatite/keratin composite porous material through a freeze-drying method; and soaking the composite porous material into a PBS (poly butylenes succinate) (pH=7.4) solution, carrying out enhancing treatment, and then carrying out freeze-drying again to obtain the hydroxyapatite-enhanced keratin composite aggregate with good mechanical property. Compared with an un-enhanced hydroxyapatite/keratin composite porous material, the enhanced composite scaffold is not fragile; the compressive strength range is 200-800KPa; the requirements of the mechanical property of a non-bearing skeleton in short-term repairing and using processes can be met; and application of the hydroxyapatite/keratin composite biological scaffold material as a bone substitution material is promoted.</description><language>eng</language><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150930&DB=EPODOC&CC=CN&NR=104941005A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150930&DB=EPODOC&CC=CN&NR=104941005A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHAI PEIYU</creatorcontrib><creatorcontrib>YU XIA</creatorcontrib><creatorcontrib>FAN JIE</creatorcontrib><creatorcontrib>LIU YONG</creatorcontrib><creatorcontrib>LEI TONGDA</creatorcontrib><title>Preparation method of hydroxyapatite-enhanced keratin composite aggregate</title><description>The invention provides a preparation method of a hydroxyapatite-enhanced keratin composite aggregate. The method specifically comprises the following steps: adding hydroxyapatite powder to a keratin solution which is extracted from a natural keratin fiber by a reduction method, and mixing the hydroxyapatite powder with the keratin solution evenly through ultrasonic dispersion; injecting a mixed solution into a mold, rapidly freezing, and then obtaining a hydroxyapatite/keratin composite porous material through a freeze-drying method; and soaking the composite porous material into a PBS (poly butylenes succinate) (pH=7.4) solution, carrying out enhancing treatment, and then carrying out freeze-drying again to obtain the hydroxyapatite-enhanced keratin composite aggregate with good mechanical property. 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The method specifically comprises the following steps: adding hydroxyapatite powder to a keratin solution which is extracted from a natural keratin fiber by a reduction method, and mixing the hydroxyapatite powder with the keratin solution evenly through ultrasonic dispersion; injecting a mixed solution into a mold, rapidly freezing, and then obtaining a hydroxyapatite/keratin composite porous material through a freeze-drying method; and soaking the composite porous material into a PBS (poly butylenes succinate) (pH=7.4) solution, carrying out enhancing treatment, and then carrying out freeze-drying again to obtain the hydroxyapatite-enhanced keratin composite aggregate with good mechanical property. Compared with an un-enhanced hydroxyapatite/keratin composite porous material, the enhanced composite scaffold is not fragile; the compressive strength range is 200-800KPa; the requirements of the mechanical property of a non-bearing skeleton in short-term repairing and using processes can be met; and application of the hydroxyapatite/keratin composite biological scaffold material as a bone substitution material is promoted.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
title	Preparation method of hydroxyapatite-enhanced keratin composite aggregate
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