Ticagrelor solid preparation and preparation method thereof
The invention relates to a ticagrelor solid preparation and a preparation method thereof. The solid preparation contains active pharmaceutical ingredients including ticagrelor and a diluent, wherein the diluent is a combination of mannitol and microcrystalline cellulose; and furthermore, the weight...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | The invention relates to a ticagrelor solid preparation and a preparation method thereof. The solid preparation contains active pharmaceutical ingredients including ticagrelor and a diluent, wherein the diluent is a combination of mannitol and microcrystalline cellulose; and furthermore, the weight proportion of mannitol to microcrystalline cellulose is 0.2:1 to 3:1. The solid preparation provided by the invention is capable of promoting drugs to dissolve out completely while accelerating drugs to dissolve out; therefore, the solid preparation is high in bioavailability and good in storage stability; furthermore, the invention further provides a preparation method of the ticagrelor solid preparation; and the preparation method is simple and feasible and low in production cost and is applied to industrial production. |
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