Diazole amides

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the i...

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Bibliographische Detailangaben
Hauptverfasser:	JAEN JUAN C, PUNNA SREENIVAS, TANAKA HIROKO, FAN PINGCHEN, ZHANG PENGLIE, POWERS JAY P, LI YANDONG, CHEN XI, DRAGOLI DEAN R, MALATHONG VIENGKHAM
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.