Simultaneous-delivery nanometer carrier and preparation method thereof

The invention discloses a nanometer carrier for simultaneous delivery of medicines and genes and a preparation method of the nanometer carrier, and particularly relates to a simultaneous-delivery nanometer carrier PLGA-pSPE (polyspermine)-PEG (polyethylene glycol)-Ligand capable of simultaneously loading medicines and genes. The medicine delivery system is realized by the following steps: synthesizing pSPE with spermine at two ends by using spermine and polyethylene glycol acrylate (PEGDA) through Michael addition reaction; generating amphipathic PLGA-pSPE from a pSPE and poly(lactide-co-glycolide) copolymer PLGA through condensation reaction of amino and carboxyl; and generating PLGA-pSPE-PEG-Ligand by using PLGA-pSPE and PEG (HOOC-PEG-Ligand) of which one end is provided with carboxyl and the other end is connected with a target head through condensation reaction of amino and carboxyl, and self-assembling to form nano particles, wherein kernel PLGA is capable of well loading insoluble medicines as a hydrophobic material; the pSPE contains a lot of secondary amino groups, is positively charged, is capable of well loading negatively charged genes and grafting an invisible material PEG with the target head; relatively good target medicine delivery can be realized under the combined action of the PEG and the target head; and the medicines and the genes are delivered to the same target cell.