2-oxo-1-pyrrolidine chiral derivative preparation method

The present invention relates to a 2-oxo-1-pyrrolidine chiral derivative preparation method, which comprises: adding a chiral catalyst and a reaction solvent to a reaction container under the protection of an inert gas, and stirring for 15-40 min; adjusting the temperature to -80-30 DEG C, and adding a reaction raw material; adding a hydrogen source to the reaction container, and carrying out a constant temperature reaction for 8-48 h at a temperature of -80-30 DEG C; after completing the reaction, adjusting the temperature to -20-30 DEG C, adding a solution a and an substance b, and stirring for 8-12 h; carrying out an extraction treatment on the reaction material, and then carrying out drying, suction filtration and concentration on the organic layer to obtain a crude product; and carrying out re-crystallization on the crude product to obtain the product. The preparation method of the present invention has advantages of low production cost, high yield, easy industrial production, and the like.