Cyclopeptide compound GG6F and preparation method thereof

The present invention belongs to the pharmaceutical field, and relates to a cyclic hexapeptide compound GG6F having a structure represented by a formula (I), and a chemical preparation method thereof, wherein six alpha-L-amino acids are sequentially bound in a head-to-tail manner to form the cyclic hexapeptide compound GG6F, and the cyclic hexapeptide compound GG6F is represented by cyclo-(Gly-Leu-Val-Leu-Leu-Phe). According to the present invention, the Wang resin is adopted as a solid phase support, HATU/HOAt is adopted as a condensing agent, N,N-dimethylformamide is adopted as a solvent, a linear peptide precursor is subjected to solid-phase synthesis, the cyclopeptide is chemically prepared through liquid phase ring closing, the reaction product GG6F is purified through column chromatography, and the structure is confirmed through NMR spectroscopy and mass spectrometry. The preparation method of the present invention has characteristics of simple step and high yield, and is suitable for preparing the pharmaceutically active cyclic hexapeptide. The formula (I) is defined in the instruction.