Preparation method for tert-butyl-(3R,5S)-6-chlorodihydroxyhexanoate

The invention discloses a preparation method for tert-butyl-(3R,5S)-6-chlorodihydroxyhexanoateand belongs to the technical field of pharmaceutical and chemical engineering. The preparation method comprises the following steps: dissolving 3,4-dioxo-6-tert-butyl chlorohexanoate in an organic solvent; carrying out catalytic hydrogenation reaction in the presence of a chiral catalyst (R)-[RuCl2 (MeO-BIPHEP)]2, wherein the said catalytic hydrogenation reaction condition is as follows: the temperature is 20 to 80 DEG C, the pressure is 0.1- .8 MPa, and the time is 1-7 hours; after the reaction, reducing the pressure to normal pressure, concentrating at a reduced pressure and distilling to obtain tert-butyl -(3R,5S)-6-chlorodihydroxyhexanoate, wherein the molar ratio of 3,4-dioxo-6-tert-butyl chlorohexanoate and the chiral catalyst is 1:(0.00005-0.0002). The preparation process disclosed by the invention is novel and simple, simple to operate, environmental-friendly and suitable for industrial production.