Novel PHBV modified induced type bone repair scaffold material
A novel PHBV modified induced type bone repair scaffold material is prepared by the steps: dissolving amino acetic acid in a sodium bicarbonate solution, to obtain a first solution; dissolving di-tert-butyl dicarbonate in dioxane, to obtain a second solution; dropwise adding the second solution into...
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Zusammenfassung: | A novel PHBV modified induced type bone repair scaffold material is prepared by the steps: dissolving amino acetic acid in a sodium bicarbonate solution, to obtain a first solution; dissolving di-tert-butyl dicarbonate in dioxane, to obtain a second solution; dropwise adding the second solution into the first solution; adjusting the pH value to neutral, dissolving the solids, dropwise adding the filtrate into cold ethyl ether, washing and drying an insoluble substance, and thus obtaining dicarbonate t-butyloxycarboryl-glycine; carrying out condensation on icariin and dicarbonate t-butyloxycarboryl-glycine, adding a mixed liquid of trifluoroacetic acid and dichloromethane into the product, and after the reaction is stopped, evaporating; dissolving the remainder with ethyl acetate; removing the solvent, to obtain aminated icariin; carrying out a condensation reaction; pouring aminated icariin-PHBV into a chitosan solution, injecting into an annular mold, freezing with liquid nitrogen, demoulding, drying, and thus obtaining the novel PHBV modified induced type bone repair scaffold material. The bone repair scaffold material can promote directional differentiation of stem cells into osteoblasts, accelerates bone growth and functional recovery, and can effectively repair bone defects. |
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