Application of N-thiazole benzoxazinone derivatives serving as neuraminidase inhibitors
The invention relates to 3-[5-(1,2,4-triazole-1-yl) thiazole-2-yl] benzoxazinone having a chemical structure formula I shown in the specification or salts thereof; in the formula, R is selected from C1-C2 alkyl and C3-C4 linear chain or C3-C4 branched alkyl; X1 is selected from H, deuterium, methyl,...
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| creator | HU AIXI XIE XUANQING ZHANG CUIYANG |
| description | The invention relates to 3-[5-(1,2,4-triazole-1-yl) thiazole-2-yl] benzoxazinone having a chemical structure formula I shown in the specification or salts thereof; in the formula, R is selected from C1-C2 alkyl and C3-C4 linear chain or C3-C4 branched alkyl; X1 is selected from H, deuterium, methyl, ethyl, C3-C4 linear chain alkyl or C3-C4 branched alkyl, F, Cl, Br or I; X2 is selected from H, deuterium, methyl, ethyl and C3-C4 linear chain alkyl or C3-C4 branched alkyl; X3 is selected from H, deuterium, methyl, ethyl, C3-C4 linear chain alkyl or C3-C4 branched alkyl, F, Cl, Br, I or nitro; X4 is selected from H, deuterium, methyl, ethyl and C3-C4 linear chain alkyl or C3-C4 branched alkyl; and the salts of 3-[5-(1,2,4-triazole-1-yl) thiazole-2-yl] benzoxazinone are selected from hydrochlorides, hydrobromides, sulfates, nitrates, phosphates, mesylates, benzene sulfonates, p-toluene sulfonic acid salts, malates, lactates, succinates, maleates or fumarates. The invention provides the application of 3-[5-(1,2,4-triazole-1-yl) thiazole-2-yl] benzoxazinone or the salts thereof in preparation of anti-neuraminidase inhibitors. |
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The invention provides the application of 3-[5-(1,2,4-triazole-1-yl) thiazole-2-yl] benzoxazinone or the salts thereof in preparation of anti-neuraminidase inhibitors.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150812&DB=EPODOC&CC=CN&NR=104829607A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150812&DB=EPODOC&CC=CN&NR=104829607A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HU AIXI</creatorcontrib><creatorcontrib>XIE XUANQING</creatorcontrib><creatorcontrib>ZHANG CUIYANG</creatorcontrib><title>Application of N-thiazole benzoxazinone derivatives serving as neuraminidase inhibitors</title><description>The invention relates to 3-[5-(1,2,4-triazole-1-yl) thiazole-2-yl] benzoxazinone having a chemical structure formula I shown in the specification or salts thereof; in the formula, R is selected from C1-C2 alkyl and C3-C4 linear chain or C3-C4 branched alkyl; X1 is selected from H, deuterium, methyl, ethyl, C3-C4 linear chain alkyl or C3-C4 branched alkyl, F, Cl, Br or I; X2 is selected from H, deuterium, methyl, ethyl and C3-C4 linear chain alkyl or C3-C4 branched alkyl; X3 is selected from H, deuterium, methyl, ethyl, C3-C4 linear chain alkyl or C3-C4 branched alkyl, F, Cl, Br, I or nitro; X4 is selected from H, deuterium, methyl, ethyl and C3-C4 linear chain alkyl or C3-C4 branched alkyl; and the salts of 3-[5-(1,2,4-triazole-1-yl) thiazole-2-yl] benzoxazinone are selected from hydrochlorides, hydrobromides, sulfates, nitrates, phosphates, mesylates, benzene sulfonates, p-toluene sulfonic acid salts, malates, lactates, succinates, maleates or fumarates. 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The invention provides the application of 3-[5-(1,2,4-triazole-1-yl) thiazole-2-yl] benzoxazinone or the salts thereof in preparation of anti-neuraminidase inhibitors.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Application of N-thiazole benzoxazinone derivatives serving as neuraminidase inhibitors |
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