Preparation method and application of vernonia anthelmintica phenolic acid part

The invention relates to a preparation method and an application of a vernonia anthelmintica phenolic acid part. The preparation method comprises the following steps of smashing dry vernonia anthelmintica fruits; extracting the drying vernonia anthelmintica fruits by using organic solvent; and performing resin separation and purification to obtain vernonia anthelmintica extracts which mainly comprise a phenolic acid compound. The content of phenolic acid in the vernonia anthelmintica phenolic acid part is 20%-99% in percentage by mass. The vernonia anthelmintica phenolic acid part also comprises the following main active ingredients in percentage by mass: 3-26% of 3, 4-dicaffeoyl-quinic acid, 5-34% of 3, 5-dicaffeoyl-quinic acid and 5-40% of 4, 5-dicaffeoyl-quinic acid. A preliminary experiment proves that the vernonia anthelmintica phenolic acid part obtained by the method has effects of increasing melanocyte in hair follicle and promoting melanogenesis and can be used for treating leukoderma. The preparation method is simple in technology and low in production cost; effective ingredients are stable; and the quality is easy to control. By the preparation method and the application of the vernonia anthelmintica phenolic acid part, a novel medicinal part and compounds are provided for treatment of the leukoderma.