Beta-glucan immunotherapeutic methods

This present invention describes, in one aspect, a method for identifying beta-glucan binding to immune cells of a subject. Generally, the method includes obtaining a blood sample from the subject, the blood sample comprising immune cells, adding soluble beta-glucan to at least a portion of the bloo...

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Bibliographische Detailangaben
Hauptverfasser:	GROSSMAN WILLIAM J, BOSE NANDITA, WALSH RICHARD M, DANIELSON MICHAEL E, NELSON MARIANA I, MICHEL KYLE S, ANTONYSAMY MARY A
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	This present invention describes, in one aspect, a method for identifying beta-glucan binding to immune cells of a subject. Generally, the method includes obtaining a blood sample from the subject, the blood sample comprising immune cells, adding soluble beta-glucan to at least a portion of the blood sample and incubating the mixture under conditions allowing the soluble beta-glucan to bind to the immune cells, and detecting soluble beta-glucan bound to the immune cells. In another aspect, the present invention describes a method that generally includes identifying the subject as a low binder of beta-glucan, and co-administering to the subject a soluble beta-glucan and an antibody preparation capable of converting the subject from a low binder to a high binder.