Process for preparing antiviral agent

Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

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Hauptverfasser: VEMISHETTI PURUSHOTHAM, KUCERA DAVID J, PRASAD SIVA JOSYULA, PATEL SUNIL S, SHI ZHONGPING, LIANG JING, RIJHWANI SUSHIL K, SINGH AMBARISH K, BIEN JEFFREY T, LEWIS CHARLES, ZHOU MAOTANG X, BANERJEE AMIT, THOTTATHIL JOHN, CHEN CHUNG-PIN H, PATEL RAMESH N, STOJANOVIC MILAN, PENDRI YADAGIRI R, CHAN YEUNG YU, WANG SHAOPENG, EVANS JEFFREY M, POLNIASZEK RICHARD P, KRONENTHAL DAVID R, POWERS GERALD L, KRISHNAMURTY DHILEEPKUMAR
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creator VEMISHETTI PURUSHOTHAM
KUCERA DAVID J
PRASAD SIVA JOSYULA
PATEL SUNIL S
SHI ZHONGPING
LIANG JING
RIJHWANI SUSHIL K
SINGH AMBARISH K
BIEN JEFFREY T
LEWIS CHARLES
ZHOU MAOTANG X
BANERJEE AMIT
THOTTATHIL JOHN
CHEN CHUNG-PIN H
PATEL RAMESH N
STOJANOVIC MILAN
PENDRI YADAGIRI R
CHAN YEUNG YU
WANG SHAOPENG
EVANS JEFFREY M
POLNIASZEK RICHARD P
KRONENTHAL DAVID R
POWERS GERALD L
KRISHNAMURTY DHILEEPKUMAR
description Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
title Process for preparing antiviral agent
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