Process for preparing tilmicosin enteric-coated pellet by centrifuge method

The invention discloses a process for preparing a tilmicosin enteric-coated pellet by a centrifuge method. The tilmicosin enteric-coated pellet is prepared from the following raw materials in percentage by mass: 21-26% of tilmicosin, 10-20% of an adhesive, 23-30% of microcrystalline cellulose and 10...

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Bibliographische Detailangaben
Hauptverfasser: NING CHUNYAN, WANG ZHENNAN, LIU YUNFU, ZENG XIANRONG, WANG XUEPING, ZHOU YUSHENG
Format: Patent
Sprache:eng
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Zusammenfassung:The invention discloses a process for preparing a tilmicosin enteric-coated pellet by a centrifuge method. The tilmicosin enteric-coated pellet is prepared from the following raw materials in percentage by mass: 21-26% of tilmicosin, 10-20% of an adhesive, 23-30% of microcrystalline cellulose and 10-20% of a coating material, and is prepared through the following steps: performing centrifugal pelleting on the raw materials, and coating the pellet obtained through centrifugal pelleting. The tilmicosin enteric-coated pellet is high in encapsulation efficiency, can mask the bitter taste of tilmicosin well, is dissolved out in an intestinal environment, can be used as an enteric-coated sustained-release reagent, solves the adverse reaction caused after the tilmicosin enteric-coated pellet is absorbed in stomach, is simple in preparation process, and is suitable for industrial large-scale production, thereby having a very wide application prospect; besides, the raw materials are cheap and easy to obtain.