Platinum compound of malonic acid derivative having leaving group containing amino or alkylamino

Disclosed are a platinum compound of malonic acid derivative having a leaving group containing an amino or alkylamino, and pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition containing the compound. Also disclosed are uses of the compound for treating...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN XIAOPING, YAN YASHI, WEN SHOUMING, MENG XIAOPING, ZHAO FENG, GAO ZEJUN
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are a platinum compound of malonic acid derivative having a leaving group containing an amino or alkylamino, and pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition containing the compound. Also disclosed are uses of the compound for treating cell proliferative diseases especially cancers. The platinum compound of the present invention has high solubility in water, low toxicity and strong anti-tumor effect.