Cationic liposomal drug delivery system for specific targeting of human cd14+ monocytes in whole blood

This invention concerns a liposome comprising lipids and at least one active ingredient, wherein at least one of the lipids is a cationic lipid; said liposome exhibiting a net positive charge at physiological conditions at which said liposome preferentially adheres to monocytes in freshly drawn bloo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ANDRESEN THOMAS LARS, JENSEN SIMON SKJOEDE, HENRIKSEN JONAS ROSAGER, JOHANSEN PIA THERMANN
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:This invention concerns a liposome comprising lipids and at least one active ingredient, wherein at least one of the lipids is a cationic lipid; said liposome exhibiting a net positive charge at physiological conditions at which said liposome preferentially adheres to monocytes in freshly drawn blood when compared to adherence to granulocytes, T-lymphocytes, B- lymphocytes and/or NK cells in freshly drawn blood, to a lipid-based pharmaceutical composition comprising said liposomes and their use in monocytic associated prophylaxis, treatment or amelioration of a condition such as cancer, an infectious disease, an inflammatory disease, an autoimmune disease or allergy.