Preparation method of 2,2-difluoro methyl piperate
The invention relates to the field of organic synthesis, in particular to a preparation method of 2,2-difluoro methyl piperate. The preparation method of the 2,2-difluoro methyl piperate includes the following steps that 2,2- difluoro piperyl fluorine (II) and methanol are reacted, 2,2- difluoro met...
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Zusammenfassung: | The invention relates to the field of organic synthesis, in particular to a preparation method of 2,2-difluoro methyl piperate. The preparation method of the 2,2-difluoro methyl piperate includes the following steps that 2,2- difluoro piperyl fluorine (II) and methanol are reacted, 2,2- difluoro methyl piperate (III) is obtained through esterification reaction, and please see the reaction formula in the specifications. The preparation method of 2,2-difluoro methyl piperate has the advantages that the synthesis route is short, the process is easy to control, reaction is complete, the yield is high, and prepared target products are high in purity, are stable in quality and completely meet the use requirements as a pesticide or medical intermediate; in addition, raw materials and reagents used in the method are cheap, the amount of solvents used in each step of reaction is small, a little waste liquid is generated, the cost is reduced, environmental pollution is reduced, and the 2,2-difluoro methyl piperate is quite convenient to produce in a large scale in a commercialization mode. |
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