Process for preparing solid oral forms containing isocyclo-phosphoamide as active substance

Solid oral ifosfamide formulations comprising a capsule containing a mass which consists essentially of the active substance ifosfamide and microcrystalline cellulose, or in the form of tablets which contain, in relation to one part by weight of ifosfamide, 0.1-1.0 parts by weight of tribasic calciu...

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Bibliographische Detailangaben
Hauptverfasser:	DIETER SAUERBIER, ECKHARD MILSMANN, JURGEN ENGEL
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Solid oral ifosfamide formulations comprising a capsule containing a mass which consists essentially of the active substance ifosfamide and microcrystalline cellulose, or in the form of tablets which contain, in relation to one part by weight of ifosfamide, 0.1-1.0 parts by weight of tribasic calcium phosphate and 0.04-0.4 parts by weight of polyethylene glycol as well as in addition, related to the weight of the tablet 5-60% by weight of a filling and flow regulating agent 1-10% by weight of a disintegrant 0.1-10% by weight of an antiadhesion agent and 0.1-80% by weight of a binding agent.