Asymmetric heterocyclic ketone Aldol reaction catalyst and reaction method thereof

The invention discloses an asymmetric heterocyclic ketone Aldol reaction catalyst. The asymmetric heterocyclic ketone Aldol reaction catalyst contains carpain protease. The invention also discloses a reaction method of the asymmetric heterocyclic ketone Aldol reaction catalyst. The invention first discloses a use of carpain protease as the asymmetric heterocyclic ketone Aldol reaction catalyst, the carpain protease is especially suitable for an asymmetric heterocyclic ketone Aldol reaction of aromatic aldehyde or hetero(aryl)aldehyde and heterocyclic ketone, and has good catalytic activity, high enantioselectivity, high economy and environment-friendliness. The asymmetric heterocyclic ketone Aldol reaction catalyst widens a carpain protease application range, is an excellent enzyme catalyst for an asymmetric heterocyclic ketone Aldol reaction and has a wide application prospect in the field of organic synthesis.