Lansoprazole enteric-coated preparation and preparation method thereof

The invention belongs to the field of medicines and particularly relates to a proton pump inhibitor lansoprazole enteric-coated preparation and a preparation method thereof. The curative effect and the medication safety of a drug are directly affected as lansoprazole is quickly degraded and discolored due to unstable property, and improper preparation or storage. In order to solve the problem, the enteric-coated preparation is prepared by three layers of coatings by taking lansoprazoleas a main drug, wherein the three layers of coatings are respectively an alkaline protective layer, an isolating layer and an enteric-coated layer from the inside to the outside; the alkaline protective layer comprises a film-forming agent, a lubricant, a light-screening agent, an alkaline stabilizer and a solvent, and a pH value of a coating liquid is 8.0-13.0; the isolating layer comprises a film-forming agent, a lubricant, a plasticizer, a light-screening agent and a solvent, and a pH value of the coating liquid is 7.0-8.0; the enteric-coated layer comprises a film-forming agent, a plasticizer, a lubricant, a light-screening agent, a stabilizer and a solvent, and a pH value of the coating liquid is 5.0-6.0. The lansoprazole enteric-coated preparation has characteristics of a short product production period and small influence by environment, temperature, humidity, and dust pollution.