Aminophylline composition freeze-dried tablet and preparation method thereof

The invention provides an aminophylline composition freeze-dried tablet and a preparation method thereof and relates to the technical field of medicines and medicine production. The aminophylline composition freeze-dried tablet is prepared from the following components including aminophylline, starc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LI BIAO, LI ZHUZHU, KONG YOUDI, RAO JINGWEI, WANG NINGQING
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides an aminophylline composition freeze-dried tablet and a preparation method thereof and relates to the technical field of medicines and medicine production. The aminophylline composition freeze-dried tablet is prepared from the following components including aminophylline, starch and sucrose. According to the aminophylline composition freeze-dried tablet provided by the invention, with the starch and the sucrose as auxiliary materials, heating process treatment is carried out on common corn starch, so that the actions of adhesion and disintegration of the starch in a tablet and the formability of the tablet are improved, and the aminophylline composition freeze-dried tablet only needs the starch and the sucrose serving as the auxiliary materials. The aminophylline composition freeze-dried tablet is prepared by adopting the freeze drying technology with twice cooling and twice temperature raising, wherein with twice cooling and twice temperature raising, the formability of the tablet is good, the dissolution of the tablet is improved, and thus the bioavailability of the tablet is improved. With the adoption of the aminophylline composition freeze-dried tablet, the disadvantages of the common aminophylline tablet are overcome, the species and the dosages of the auxiliary materials in the aminophylline tablet are reduced, the dissolution of the tablet is large, the bioavailability of the tablet is high, and the curative effect and the safety of clinical medication are ensured.