Synthesis method of 3,4,5-triphenyl pyrazole

The invention provides a novel method of synthesizing 3,4,5-triphenyl pyrazole. The method comprises the steps of adding reaction raw materials, i.e., 1,2-diphenyl acrylonitrile, potassium carbonate and benzaldehyde p-toluenesulfonhydrazide hydrazone at a molar ratio of 1:2:2 into DMF (Dimethyl Form...

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Hauptverfasser: JING XIAOBI, WANG LEI, TAN XIAODONG, YUAN DANDAN, LU HAILONG, SHEN MING
Format: Patent
Sprache:eng
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Zusammenfassung:The invention provides a novel method of synthesizing 3,4,5-triphenyl pyrazole. The method comprises the steps of adding reaction raw materials, i.e., 1,2-diphenyl acrylonitrile, potassium carbonate and benzaldehyde p-toluenesulfonhydrazide hydrazone at a molar ratio of 1:2:2 into DMF (Dimethyl Formamide), uniformly mixing, then heating to 95-105 DEG C, keeping reaction liquid warm till the reaction finishes, pouring a mixture into a certain amount of water, then extracting with ethyl acetate, and after steaming and removing a solvent by an organic phase, separating residuals via thin layer chromatography to form 3,4,5-triphenyl pyrazole. The method is simple to implement and has a higher practical value.