Method for preparing polymer nanoparticles by taking inactivated rabies virus vaccine as template

The invention relates to a method for preparing polymer nanoparticles by taking an inactivated rabies virus vaccine as a template. The inactivated rabies virus vaccine is taken as a biological template, and the polymethyl methacrylate, polystyrene, polyacrylic acid and polyacrylamide nanoparticles a...

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Hauptverfasser: HUANG SHANRAN, WANG TITI, HUANG WEI, HUANG JITAO
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creator HUANG SHANRAN
WANG TITI
HUANG WEI
HUANG JITAO
description The invention relates to a method for preparing polymer nanoparticles by taking an inactivated rabies virus vaccine as a template. The inactivated rabies virus vaccine is taken as a biological template, and the polymethyl methacrylate, polystyrene, polyacrylic acid and polyacrylamide nanoparticles are prepared. The preparation method comprises the following steps: coating silica gel on the surface of virion by virtue of a sol-gel reaction of tetraethyl orthosilicate, and decomposing the template at high temperature, and forming a silica matrix; immersing a polymer monomer solution into a silicon matrix, and polymerizing and curing in a limited micro space; and decomposing the silica matrix, thereby obtaining the polymethyl methacrylate, polystyrene, polyacrylic acid and polyacrylamide nanoparticles. The product can serve as a carrier of drug delivery and supported catalyst, and the process method can be used for simulating the morphology of microbial biomass so as to synthesize the nanoparticles. The obtained product is not limited to the symmetrical and regular geometrical shape and can be used for imitating the uniform size and complex morphology of the microbial biomass.
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subjects CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
THEIR RELEVANT APPARATUS
TRANSPORTING
title Method for preparing polymer nanoparticles by taking inactivated rabies virus vaccine as template
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