Animal model of CA16 virus infected gerbil and application thereof

The invention discloses an animal model of a CA16 virus infected gerbil and an application thereof in evaluating vaccines. The method is implemented through injecting a CA16 virus into an infected gerbil in an intraperitoneal injection mode, so that the gerbil infected with the CA16 virus is obtaine...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ZHU HANPING, ZHOU XIAOLONG, XIE RONGHUI, YANG ZHANGNV, LU HANGJING, YAO PINGPING, ZHU ZHIYONG, SUN YISHENG, CHEN ZHIPING, XU FANG
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses an animal model of a CA16 virus infected gerbil and an application thereof in evaluating vaccines. The method is implemented through injecting a CA16 virus into an infected gerbil in an intraperitoneal injection mode, so that the gerbil infected with the CA16 virus is obtained, wherein the injection amount per gerbil is 1.010-1.010 TCID50. The model disclosed by the invention greatly simulates the lesions of clinical patients infected with the CA16 virus occurring in the aspect of nervous systems such as tissues brain stems and spinal cords, but existing neonatal rat models do not have the function; and in combination with an existing EV71 virus infected gerbil model, the animal model disclosed by the invention can be used as an animal model for evaluating the protective effect of EV71/CA16 duplex vaccines.