New benzofurans suitable as precursors to compounds that are useful for imaging amyloid deposits

The invention is suitable for new benzofurans suitable as precursors to compounds that are useful for imaging amyloid deposits. The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SCHOU PER MAGNUS, RUDA KATINKA, DELISSER VERN, BJOERK SETH, NILSSON NILS ANDERS, SWAHN BRITT-MARIE, JOHNSTROEM PETER
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The invention is suitable for new benzofurans suitable as precursors to compounds that are useful for imaging amyloid deposits. The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. The compounds deriving from these precursors are useful in methods of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease by positron emission tomography (PET) as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents. Furthermore, the present invention also discloses the precursor compounds in crystalline form.