Method for detecting methyl methane sulfonate by gas chromatography and tandem mass spectrometry

The invention discloses a method for detecting methyl methane sulfonate by gas chromatography and tandem mass spectrometry. The method is characterized by comprising the following steps: (1) placing a sample to be detected into a volumetric flask, adding acetonitrile to make up to the volume of 10 to 25 ml, carrying out vortex mixing for 1 to 5 min, carrying out ultrasonic extraction for 10 to 15 min, sieving the obtained product by a filter membrane with the specification of 0.22 [mu]m and carrying out sample injection to detect the methyl methane sulfonate in the sample; (2) under the detection conditions, using a gas chromatography and tandem mass spectrometry combined instrument GC-MS/MS as a detection instrument for detecting the methyl methane sulfonate. In the step (1), 0.05 to 0.50 g of the sample to be detected is taken, accuracy reaches 0.1 mg, the sample to be detected is placed in the volumetric flask, the acetonitrile is added to make up to the volume of 10 to 25 ml, vortex mixing is carried out for 1 to 5 min and ultrasonic extraction is carried out for 10 to 15 min. the method can simply, rapidly, conveniently and efficiently carry out qualitative and quantitative detection on MMS (methyl methane sulfonate) in medicine raw materials, chemical reagents and foods by using the GC-MS/MS.