Fenofibrate composition and preparation thereof
The invention belongs to the technical field of medicine preparation, and particularly relates to a fenofibrate composition and a preparation thereof. The fenofibrate composition comprises the following components in parts by weight: 100 parts of fenofibrate, 80-100 parts of a filler, 0.5-1.5 parts...
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Sprache: | eng |
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Zusammenfassung: | The invention belongs to the technical field of medicine preparation, and particularly relates to a fenofibrate composition and a preparation thereof. The fenofibrate composition comprises the following components in parts by weight: 100 parts of fenofibrate, 80-100 parts of a filler, 0.5-1.5 parts of an adhesive, 5-15 parts of a disintegrating agent, 0.5-3 parts of a lubricating agent and 0.5-3 parts of a surfactant, wherein the mean particle size of the fenofibrate is controlled between 10 microns and 20 microns. Compared with the prior art, according to the fenofibrate composition disclosed by the invention, the raw materials are subjected to micronization treatment; the particle sizes are controlled to be between 10 microns and 20 microns; and after the preparation is prepared, the dissolution rate of the fenofibrate can be increased, thus the bioavailability of the preparation is improved; and the stability of the preparation is also improved. |
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