Preparation method of tenofovir disoproxil fumarate impurities

Preparation method of tenofovir disoproxil fumarate impurities

The invention relates to a novel synthesis method of three impurities of tenofovir disoproxil fumarate, and the method has an important significance for synthesizing high-quality tenofovir disoproxil fumarate. The invention mainly aims at researching the synthesis of a tenofovir disoproxil fumarate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHENG HEHONG, CHEN GUOHUA, LIN QINGZHI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a novel synthesis method of three impurities of tenofovir disoproxil fumarate, and the method has an important significance for synthesizing high-quality tenofovir disoproxil fumarate. The invention mainly aims at researching the synthesis of a tenofovir disoproxil fumarate isopropyl ester impurity (R)-9-(2-phosphonomethoxy propyl) adenyl isopropyl oxycarbonyl methoxy isopropyl ester (IV), a tenofovir disoproxil fumarate methoxycarbonyl methoxy ester impurity (R)-9-(2-phosphonomethoxy propyl) adenyl isopropyl oxycarbonyl methoxy ester methoxycarbonyl methoxy ester (VI) and a tenofovir disoproxil fumarate n-propyl oxycarbonyl methoxy ester impurity (R)-9-(2-phosphonomethoxy propyl) adenyl isopropy oxycarbonyl methoxy ester n-propyl oxycarbonyl methoxy ester (VII). The synthetic routes of the three impurities of tenofovir disoproxil fumarate are as shown in the specification.