Crystalline pi3 kinase inhibitors

Crystalline pi3 kinase inhibitors

There is provided inter alia 6-(2-((4-arnino-3-(3-hydroxyphenyl)-1 H-pyrazolo[3,4-d]pyrirnidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5- ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also p...

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Bibliographische Detailangaben
Hauptverfasser: COPMANS ALEX HERMAN, LEYS CARINA, FILLIERS WALTER FERDINAND MARIA, NIESTE PATRICK HUBERT J, VANHOUTTE FILIP MARCEL C, BROECKX RUDY LAURENT MARIA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:There is provided inter alia 6-(2-((4-arnino-3-(3-hydroxyphenyl)-1 H-pyrazolo[3,4-d]pyrirnidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5- ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.