Nitric oxide donor derivatives of bendamustine hydrochloride and preparation method of nitric oxide donor derivatives

Nitric oxide donor derivatives of bendamustine hydrochloride and preparation method of nitric oxide donor derivatives

The invention relates to nitrogen mustard antitumor drugs, namely nitric oxide donor derivatives of bendamustine and a preparation method of the nitric oxide donor derivatives. The general formula of a nitro-oxo derivative of bendamustine is as shown in the formula (I); the general formulas of furaz...

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Hauptverfasser: TANG KEHUI, GAO WENLEI, LI SHAOHUA, ZHAO JUN, DU WEIHONG, CAO SHENGHUA, YE JIALIN, WANG FANGTONG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to nitrogen mustard antitumor drugs, namely nitric oxide donor derivatives of bendamustine and a preparation method of the nitric oxide donor derivatives. The general formula of a nitro-oxo derivative of bendamustine is as shown in the formula (I); the general formulas of furazan nitrogen oxide derivatives of bendamustine are as shown in formulas (II) and (III); and the general formula of a benzofurazan nitrogen oxide derivative of bendamustine is as shown in the formula (IV).