Synthetic process of manidipine hydrochloride

Synthetic process of manidipine hydrochloride

The invention discloses a synthetic process of manidipine hydrochloride. The method uses N-hydroxyethyl piperazine as an initial raw material, which is subjected to diketene acylation, and then condensation with m-nitrobenzaldehyde and 3-amino methyl crotonate to obtain the manidipine; and the manid...

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Hauptverfasser: GU ZHIYONG, CHI XIAONA, LYU YAJUN, XU ANNA
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Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator GU ZHIYONG
CHI XIAONA
LYU YAJUN
XU ANNA
description The invention discloses a synthetic process of manidipine hydrochloride. The method uses N-hydroxyethyl piperazine as an initial raw material, which is subjected to diketene acylation, and then condensation with m-nitrobenzaldehyde and 3-amino methyl crotonate to obtain the manidipine; and the manidipine is subjected to hydrogen chloride organic solvent salt forming to obtain the manidipine hydrochloride. The invention improves synthetic process of 1-benzhydryl-4-(2-hydroxy ethyl) piperazine; and a catalyst is introduced into the diketene acylation reaction, and the salt forming process uses a novel hydrogen chloride organic solvent method, so as to ensure product quality, improve yield and facilitate industrial production.
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The invention improves synthetic process of 1-benzhydryl-4-(2-hydroxy ethyl) piperazine; and a catalyst is introduced into the diketene acylation reaction, and the salt forming process uses a novel hydrogen chloride organic solvent method, so as to ensure product quality, improve yield and facilitate industrial production.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20150121&amp;DB=EPODOC&amp;CC=CN&amp;NR=104292150A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20150121&amp;DB=EPODOC&amp;CC=CN&amp;NR=104292150A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GU ZHIYONG</creatorcontrib><creatorcontrib>CHI XIAONA</creatorcontrib><creatorcontrib>LYU YAJUN</creatorcontrib><creatorcontrib>XU ANNA</creatorcontrib><title>Synthetic process of manidipine hydrochloride</title><description>The invention discloses a synthetic process of manidipine hydrochloride. 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Synthetic process of manidipine hydrochloride
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