Synthetic process of manidipine hydrochloride

The invention discloses a synthetic process of manidipine hydrochloride. The method uses N-hydroxyethyl piperazine as an initial raw material, which is subjected to diketene acylation, and then condensation with m-nitrobenzaldehyde and 3-amino methyl crotonate to obtain the manidipine; and the manidipine is subjected to hydrogen chloride organic solvent salt forming to obtain the manidipine hydrochloride. The invention improves synthetic process of 1-benzhydryl-4-(2-hydroxy ethyl) piperazine; and a catalyst is introduced into the diketene acylation reaction, and the salt forming process uses a novel hydrogen chloride organic solvent method, so as to ensure product quality, improve yield and facilitate industrial production.