Synthetic method of amiodarone hydrochloride

The invention provides a synthetic method of an antiarrhythmic medicament amiodarone hydrochloride described in the specification, and belongs to the field of medicament synthesis. The synthetic method comprises the following steps: using salicylaldehyde as a starting material to react with 2-halogenated hydrocarbyl hexanoate, p-methoxybenzoyl chloride, iodine and 2-diethylaminoethyl chloride hydrochloride in sequence in the presence of a catalyst to gradually obtain 2-butylbenzofuran, 2-butyl-3-(4-hydroxyl benzoyl) benzofuran, 2-butyl-3-(3,5-diiodine-4-hydroxyl benzoyl) benzofuran and (2-butyl-3-benzofuryl)[4-[2-(diethylamino) ethyoxyl]3,5-diiodine pehyl] ketone hydrochloride, namely amiodarone hydrochloride. The synthetic method disclosed by the invention is simple in process, convenient to operate, good in safety performance and high in yield.