Duck hepatitis virus (DHV) I type VP1 protein inhibitory peptide and application thereof
The invention discloses a duck hepatitis virus (DHV) I type VP1 protein inhibitory peptide and application thereof, and belongs to the technical field of animal virus molecular biology. The inhibitory peptide is characterized in that DHV-1VP1 protein is obtained by means of a gene engineering method...
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Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a duck hepatitis virus (DHV) I type VP1 protein inhibitory peptide and application thereof, and belongs to the technical field of animal virus molecular biology. The inhibitory peptide is characterized in that DHV-1VP1 protein is obtained by means of a gene engineering method; and the DHV-1VP1 protein is used as a target, and a phage 12 peptide library is utilized for screening, so that the inhibitory peptide specifically bound with the DHV-1VP1 is obtained, and the amino acid sequence of the inhibitory peptide is LLADTTHHRPWT. Tests prove that the DHV I type VP1 protein inhibitory peptide is capable of inhibiting proliferation of DHV-1 in duck embryo fibroblasts, remarkably reducing the virus copy number of the DHV-1 in the duck embryo fibroblasts under different concentrations, and remarkably reducing the virus titer of the DHV-1 in the duck embryo fibroblasts. The DHV I type VP1 protein inhibitory peptide can be used for preparing anti-DHV medicines or feed additives, and has excell |
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