Duck hepatitis virus (DHV) I type VP1 protein inhibitory peptide and application thereof

The invention discloses a duck hepatitis virus (DHV) I type VP1 protein inhibitory peptide and application thereof, and belongs to the technical field of animal virus molecular biology. The inhibitory peptide is characterized in that DHV-1VP1 protein is obtained by means of a gene engineering method...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: HE LEI, ZHANG CHUNJIE, WANG CHEN, LI XIAOKANG, NIU MINGMEI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a duck hepatitis virus (DHV) I type VP1 protein inhibitory peptide and application thereof, and belongs to the technical field of animal virus molecular biology. The inhibitory peptide is characterized in that DHV-1VP1 protein is obtained by means of a gene engineering method; and the DHV-1VP1 protein is used as a target, and a phage 12 peptide library is utilized for screening, so that the inhibitory peptide specifically bound with the DHV-1VP1 is obtained, and the amino acid sequence of the inhibitory peptide is LLADTTHHRPWT. Tests prove that the DHV I type VP1 protein inhibitory peptide is capable of inhibiting proliferation of DHV-1 in duck embryo fibroblasts, remarkably reducing the virus copy number of the DHV-1 in the duck embryo fibroblasts under different concentrations, and remarkably reducing the virus titer of the DHV-1 in the duck embryo fibroblasts. The DHV I type VP1 protein inhibitory peptide can be used for preparing anti-DHV medicines or feed additives, and has excell